Chunk #4 — Results — Single-nucleotide variant analysis in individuals of European-ancestry

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Discovery of novel heart rate-associated loci using the Exome Chip.

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We observed a high correlation of effect sizes and P-values between the RR-interval and RR-INVN meta-analyses (r2 = 0.99 and 0.98, respectively; Supplementary Material, Fig. S2). Furthermore, the RR-interval was near-normally distributed, so inverse normalization was deemed unnecessary (Supplementary Material, Fig. S3).