The current analysis identified robust genetic correlation of AD with a broad variety of psychiatric outcomes. This correlation is strongest for aspects of negative mood, including neuroticism and major depression, as also seen in twin studies35,36 and through recent specific molecular evidence for pleiotropy37,38. Taken together with evidence from other recent genomic studies37, and null correlations for other GWAS of alcohol consumption, but not for measures of problem drinking (e.g., AUDIT-P), these findings suggest that major depression may primarily share genetic liability with alcohol use at pathological levels.
