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Chunk #29 — Discussion

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A 22-Year Follow-Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism.
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This paper presents results of the largest and longest prospective follow-up of individuals with AUDs for whom detailed baseline information had been gathered by the same research group almost two decades earlier. The current protocol is the first step in preparing for a more costly and intensive study of a broader group of COGA participants, including those without AUDs and comparison subjects. In this step, the data gathered over a one-year period demonstrated subjects could be found, death outcomes could be established, 95% of located subjects agreed to be interviewed, and all interviewees agreed to future follow-ups. The data gathered allowed for analyses to evaluate five hypotheses regarding potential baseline predictors of four a priori established outcome categories.