Table 2 shows association results for the Table 1 SNPs; Supplementary Table 2 shows all 76 SNPs. The most significant SNP in the combined sample is the non-synonymous CHRNA5 SNP rs16969968 (p = 4.49×10−8, OR = 1.42 (95% CI 1.25–1.61)). Furthermore, rs16969968 is the most significant of the 76 SNPs in the AAs alone (p = 0.0147, OR = 2.04 (1.15–3.62)) and in the EAs alone(p = 4.14×10−7, OR = 1.40 (1.23–1.59)). The same allele (A) is elevated in EA and AA cases. Additional SNPs correlated with rs16969968 in EAs and AAs are also significant.
