The prevalence of respondent lifetime alcohol dependence by childhood or adolescent parental divorce/separation status and parental history of alcohol problems was calculated with cross-tabulations. The simultaneous effect of childhood or adolescent parental divorce/separation and parental history of alcohol problems on offspring lifetime alcohol dependence was calculated using a logistic regression model with an interaction term, first unadjusted and then adjusted for the influence of parental history of drug, depression, and antisocial behavior problems. F-tests were used to estimate the statistical significance of the inclusion of the interaction term in the model. Odds ratios and 95% confidence intervals were derived from the beta estimates in the logistic regression model. To adjust for the complex sample characteristics of the NESARC, all analyses were conducted using SUDAAN (Research Triangle Institute, 2004). This software adopts Taylor series linearization to take into account the design effects of the NESARC.
