involved in the association belong to β-strands connecting loops projected by blades I to III towards the same region of the tertiary structure next to the “entry” face (4B; Table S3, related to Figure 4). The FLRT3-LRR remaining repeats and the capping LRRCT show only few residues (Arg275, Gln299, Lys326, Asn328 and Arg330) partly buried by the LPHN3-OLF fragment 261–267 (Table S3, related to Figure 4). The calculated total solvent-accessible area buried in the interface is 867 Å2 and this interface was computationally assigned as biologically relevant by the EPPIC server (data not shown).
