Additional interesting findings include amyloid beta enrichment for AD and PD, and tau enrichment for MS and PD (Table 1), supporting amyloid beta and tau pathology in degenerative disorders26,27. We also observed Wnt/β-catenin pathway enrichment for a number of brain disorders including ASD, SCZ, MDD, PD, MS and ALS. Wnt/β-catenin signaling is a key pathway for neurogenesis and cortical pattern specification, and its dysregulation has been observed in several psychiatric disorders28. Notably, genes involved in vocalization were associated with ASD, diagnostic criteria of which include impairment in vocalization29. We also identified brain regions (e.g. cortex, hippocampus, substantia nigra, and hypothalamus) associated with multiple brain disorders. This is intriguing as we used cortical Hi-C data.
