Brain disorders often exhibit different cellular signatures and vulnerability, highlighting the need to identify critical cell types for brain disorders to develop proper therapeutic strategies. For example, ASD postmortem brains exhibit cell-type specific gene expression signatures such as upregulation of glial genes and downregulation of neuronal genes30. Common variation in SCZ maps onto specific groups of cells including pyramidal neurons and medium spiny neurons31. Microglia are increasingly recognized as a central cell type contributing to the etiology of AD32.
