INRICH (Lee et al. 2012) was selected to conduct our pathway analyses as it is well-suited for testing both large (i.e., exploratory) and small (i.e., candidate) pathway sets. We took two, complementary approaches to pathway analysis: first, we sought to confirm previously proposed candidate gene pathways (Hodgkinson et al., 2008); second, we conducted an exploratory analysis aimed at identifying novel pathways involved in BD (The Gene Ontology Consortium, 2000). Additional details of the pathway analysis methods are discussed in the Supplemental Materials.
