models, and the predicted protein does not directly interact with other proteins or pathways currently recognized as being important to HR. Chromatin interactions in heart tissue indicate SCD and SLF2 as two other candidate genes for consideration at this locus. SCD encodes a stearoyl-CoA desaturase, which has a role in myocardial dysfunction (25) and SLF2 encodes the SMC5–SMC6 complex localization factor 2. TESK2, C10orf71 and DALRD3 can be considered as candidates for further analyses, based on the lead SNVs being non-synonymous variants in each gene. TESK2 encodes a serine/threonine protein kinase with an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases. TESK2 is ubiquitously expressed, but its function is unknown (26). There is also support for TESK2 from the chromatin interaction analyses. C10orf71 encodes an open reading frame of unknown function that is highly expressed in heart and skeletal muscle. Chromatin interaction analyses indicate MAPK8 as a second candidate gene at the C10orf71 locus, MAPK8 is involved in formation of the heart as well as HR regulation (27,28). DALRD3 encodes a protein with a DALR anticodon-binding domain similar to that of class Ia aminoacyl tRNA synthetases
