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Chunk #75 — WHAT IS KNOWN FROM GWAS STUDIES — An example of 3′UTR genetic regulation predisposing to autoimmunity

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Genetic variants in mRNA untranslated regions.
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By applying this approach to autoimmune diseases and immune-related quantitative parameters, we recently identified a genetic variant localized in the 3′UTR of the TNFSF13B gene that increased the stability and translation of the corresponding mRNA, and having a pivotal role in autoimmunity.17