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Chunk #74 — WHAT IS KNOWN FROM GWAS STUDIES — An example of 3′UTR genetic regulation predisposing to autoimmunity

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Genetic variants in mRNA untranslated regions.
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The resulting genetic association data of quantitative traits will then be compared with case-control studies for pathologies in order to identify those genetic variants associated with both a quantitative trait and a disease. This approach can reveal disease-related endophenotypes, thus helping on one hand to identify causal variant(s) at a locus and, on the other hand, to elucidate disease etio-pathogenesis.