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Chunk #22 — Results — Effects of Childhood Disorders on Subsequent Substance Use Disorders — Gender of Offspring as a Moderating Variable

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Psychopathology in offspring from families of alcohol dependent female probands: a prospective study.
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To test the impact of gender on relationship between these disorders and SUD outcome, analyses were performed using ADHD and Conduct Disorder as predictors of SUD within each gender. A significant relationship was seen for both males (Wald = 28.86, df =1, p =<0.001) and females (Wald = 17.74, df =1, p =<0.001) for Conduct Disorder. The odds ratio for developing SUD in association with a prior diagnosis of Conduct disorder in males was 15.2 (95% CI: 5.6, 41) and for females 6.05 (95% CI: 2.6, 13.9). For ADHD, a significant effect was seen for males (Wald = 6.23, df =1, p =0.013) and for females (Wald = 15.81, df =1, p =<0.001). The odds ratio for developing SUD in association with a prior diagnosis of ADHD for males was 3.69 (95% CI: 1.3, 10.3) and was greater for females 5.80 (95% CI: 2.4, 13.8).