Both female and male offspring from maternal multiplex AD families are at increased risk for Conduct Disorder with 26.1% and 15.8% diagnosed by age 19 (Figure 7). Female and male offspring from multiplex families are also at increased for ADHD with 28.3% of males and 17.5 % of females with ADHD. Because Conduct Disorder and ADHD are highly predictive of later development of SUD, it would appear that gender equality for these disorders may set the stage for the similar rates of SUD seen in male and female offspring from these maternal AD families.
