OMIM reports gene-trait links, but the GWAS Catalog reports SNP-trait links which must be converted to gene-trait links via SNP-gene links. Although methods for creating SNP-gene links have since advanced [20], we closely follow the approach of [3] with updated data sources to reduce our degrees of freedom for overfitting to new data and to make our new estimates of the effect of genetic evidence comparable to the original estimates. Our gene-trait mapping procedure attempts to replicate that used by Nelson et al. with updated data sources. An LD expansion of GWAS Catalog reported variants was performed using an LD threshold of 0.5 in the 1000 Genomes Phase 3 EUR super population [27]. A distance-based gene-trait association was established when an LD SNP was within 5000 b.p. of the gene in hg38 as annotated by SNPEff [21]. An eQTL-based gene-trait link was established when an LD SNP was reported associated with a gene with nominal p-value less than 10−6 in any GTEx tissue [13]. Using a cutoff of 10−12 makes little difference to results (S20 Table). A DHS-based gene-trait link
