Chunk #26 — Materials and methods — Data sources — Genetic data

Source

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval.

Embedded

yes

Text

Genetic association data was obtained from the GWAS Catalog [10] downloaded 2018-11-18. OMIM data was downloaded from [15] on 2018-11-18. GWAS Catalog associations with reported p-value greater than 10−8 were excluded, following the original analysis, as were OMIM provisional associations, drug response associations, and somatic variant associations.