The community sample includes 4793 participants between the ages of 12–18 from a variety of CADD projects including the Colorado Twin Registry, Colorado Adoption Project, and Family Control Samples. The twin sample consists of 3282 individuals from 1386 adolescent twin pairs and 510 siblings of twins recruited from the general population. The adoption sample consists of a total of 700 individuals including adoptees, matched controls, and their siblings. The Family Control sample includes 811 control probands and their siblings, the control probands were matched on age, sex, and ethnicity to adolescents from the clinical and adjudicated samples. Details of recruitment procedures and demographics are provided elsewhere 23–25. For families with multiple participants the data were weighted for analyses so that each family comprised a single observation (e.g., in families with three siblings, the data were weighted .33, .33, .34). This weighting allows for extraction of the maximum amount of information by including the response patterns of all individuals while limiting each family in the analyses to a single observation.
