Chunk #32 — Results — A single effective sample size does not capture all variance inflations in genotype frequency estimations, but it provides a good approximation

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Effective sample size: Quick estimation of the effect of related samples in genetic case-control association analyses.

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We illustrate these properties by the example of sibpairs. Using Eq.(8,9,3), the genotype-specific sample size reductions are: (12)αAA,sibpair=11+(1+3p)/(4+4p)αAB,sibpair=11+(1−3pq)/(2−4pq)αBB,sibpair=11+(1+3q)/(4+4q).