The loci included in our targeted capture library were as follows: genes identified through published GWAS of alcohol (Schumann et al., 2011); human alcohol dehydrogenases (N=8) and aldehyde dehydrogenases (N=20), the key enzymes involved in alcohol metabolism(Edenberg, 2007); reward system genes, including dopaminegic and opioids receptors and related metabolic genes (N=14); and the remaining space on the array was filled through prioritization of remaining candidate genes as described in the supplementary material (N=29). After collapsing neighboring genes into single loci and removing difficult to align repetitive elements, our selection encompassed 71 unique loci, covering a total of 5.5 Mb.
