In the SpiroMeta study, we generated a comprehensive dataset to analyse associations between genetic variants and lung function in the general population [7]. There have been many small previous studies, mostly of individual candidate genes examining association with lung function, which have produced conflicting results. Therefore, in this paper, we undertook a comprehensive literature review to identify relevant gene regions and analysed potential associations with FEV1 and FEV1/FVC ratio in all individuals within SpiroMeta. In addition, given the impact of smoking on lung function, we also analysed the associations separately in ever-smokers. There were no strong association signals in never-smokers group (data available on request).
