The additional genes identified in this analysis for association with FEV1 among all individuals were the transient receptor potential cation channel, subfamily V, member 4 (TRPV4) on chromosome 12, and N-acetyltransferase 2 (NAT2) on chromosome 8. Among ever-smokers, association results for FEV1 identified B-cell CLL/lymphoma 2 (BCL2) on chromosome 18. Association results for FEV1/FVC ratio identified allograft inflammatory factor 1(AIF1) on chromosome 6 among all individuals, and cluster of differentiation; CD22 molecule (CD22) on chromosome 19 among ever-smokers. The region association plots for the most significant loci in table 2 and not presented earlier are shown in figure S3 in the online supporting information. The plots show some additional support for all presented loci except for ABCC1 among ever-smokers.
