Together, these studies highlight the utility of hiPSC-derived CNS cells for exploring genetically complex neuropsychiatric disorders. Table 1 lists recent publications utilizing hiPSCs for investigating polygenic neuropsychiatric diseases (for reviews, see (Ardhanareeswaran et al., 2017; Prytkova and Brennand, 2017; Shi et al., 2017; Soliman et al., 2017). Though some caveats and limitations exist (discussed below), the rapidly advancing field of hiPSC differentiation and associated analytical platforms is rife with potential.