Chunk #20 — 3. Results — 3.3. Evaluating the interaction between the 5-HTTLPR short allele and childhood maltreatment in predicting cross-sectional snapshots of adult depression

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Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results.

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Next, we evaluated G×E. In general, carriers of two 5-HTTLPR short alleles who were exposed to definite/severe maltreatment had the highest risk of depression (Fig. 2). However, statistical tests of G×E did not follow a predictable pattern across the four measurement occasions (Table 3). In both Dunedin and E-Risk, there was evidence of a significant G×E on two out of the four measurement occasions in adulthood.