SNPs which have been found to be associated with the disorder in the GWAS with p<1×10-3 or which were found to lie in a SNP cluster (cluster definition: ≥2 SNPs with p ≤1×10-2 and at least one SNP with p<1×10-3 in a distance of <30kb) (see, e.g., eFigures 2-4) were taken forward to the follow-up study if they were located in a homolog of a rat gene showing differential brain expression with long-term high ethanol consumption compared to their respective controls without ethanol access. Only one SNP was selected for each gene. If more than one SNP in the gene fulfilled the above mentioned criteria, the SNP with the highest number of assigned transcripts (Sullivan et al., annotation file: https://slep.unc.edu/evidence/) was taken forward. In cases of similar transcript numbers, the SNP with the lowest p-value was chosen.
