After accounting for covariates, the (non-significant) odds ratios suggested a trend toward overrepresentation of minor alleles in cases compared to controls, which is opposite the direction of effect reported by Hodgkinson et al. (2010). For three of the SNPs (rs6656912, rs6681460, rs10789215), the regression weight for the continuous phenotype (ASx) was negative, compared to an odds ratio greater than one for the dichotomous phenotype (ADx). These inconsistencies in direction of effect highlight the non-significance of association between these SNPs and alcohol dependence in the current sample.
