Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power.
- Authors
- Derringer, Jaime; Krueger, Robert F; Manz, Niklas; Porjesz, Bernice; Almasy, Laura; Bookman, Ebony; Edenberg, Howard J; Kramer, John R; Tischfield, Jay A; Bierut, Laura J
- Year
- 2011
- Journal
- Psychiatric genetics
- PMID
- 21317682
- DOI
- 10.1097/YPG.0b013e32834371fd
- PMCID
- PMC3139721
A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.
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| Name | Type |
|---|---|
| AA | cohort |
| ADx local | phenotype |
| African American | cohort |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| Alcoholic status local | phenotype |
| alcohol symptom counts local | phenotype |
| alcohol use disorders | phenotype |
| ASx local | phenotype |
| Bierut et al., 2010 local | cohort |
| Collaborative Study on the Genetics of Alcoholism (COGA) | cohort |
| current sample | cohort |
| EA | cohort |
| European ancestry | cohort |
| Hodgkinson et al., 2010 local | cohort |
| original study local | cohort |
| parietal cortex | anatomy |
| Plains Indians local | cohort |
| posterior region | anatomy |
| Pz | anatomy |
| Resting EEG theta local | phenotype |
| resting theta EEG power local | phenotype |
| rs10789215 local | variant |
| rs6656912 local | variant |
| rs6681460 local | variant |
| selected SNPs in SGIP1 local | variant |
| SGIP1 | gene |
| SGIP1 SNP local | variant |
| SGIP1 SNPs local | variant |
| substance use | phenotype |
| symptom count | phenotype |
| theta EEG power local | phenotype |
| theta oscillations | phenotype |
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In this knowledge base
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|---|---|---|---|---|
| The collaborative study on the genetics of alcoholism: Genetics. | Johnson EC et al. | — | 2023 | → |
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| Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations. | Azarnia Tehran D et al. | — | 2019 | → |
| Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study. | Malone SM et al. | — | 2014 | → |
| Evidence for a genetic component for substance dependence in Native Americans. | Ehlers CL et al. | — | 2013 | → |