both recently identified as being genetically associated with celiac disease [21], exhibited significant cis-regulation in the celiac peripheral blood dataset but not in the HapMap B cell line dataset. Cis-effects for these two genes could be detected as these two genes showed markedly upregulated expression in the celiac peripheral blood dataset (expression rank order 12,072 vs. 6,431 and 11,104 vs. 3,602, respectively). These results indicate that the analysis of different cell types is valuable to gain insight in the potential functional consequences of disease associated genetic variants.
