in mice. In addition to an effect on ethanol sedation, reducing Lmo3 levels also correlated with decreased ethanol consumption, suggesting that Lmo3 may play a role in alcohol preference in mammals. In another study, Wang and colleagues used quantitative PCR to measure LMO1 expression in a set of 23 tumors. They reported that rs110419, a variant in LMO1, is associated with LMO1 mRNA expression (p = 0.01) (Wang et al. 2011). This SNP showed nominal association with maxdrinks (p = 1.29 × 10−4) and is also in strong LD (R2 = 0.93, D′ = 0.96) with the strongest SNP rs4758317 (p = 7.2 × 10−7) in the present study. LMO1 was also nominally significant in gene-based association analysis performed using VEGAS (p = 0.01).
