Another genetic locus of interest is a 200 kb region, where 93 SNPs spanning phospholipase C-like 1 (PLCL1) on the long arm of chromosome 2, showed evidence of association in both COGA (7.21 × 10−3 ≤ p ≤ 2.71 × 10−2) and SAGE (2.80 × 10−3 ≤ p ≤ 1.22 × 10−4) subjects (Supplement figure 5). This protein was first identified as a novel inositol 1,4,5-triphosphate binding protein. It has a number of binding partners including GABA(A) receptor associated protein and beta subunits of GABA(A) receptors. PLCL1 is part of biological processes such as intracellular signal transduction, lipid metabolism and behavior (KEGG http://www.genome.jp/kegg). We used online function prediction programs like HaploReg (Ward and Kellis 2012), Polyphen (Adzhubei et al. 2010) and SCAN (http://www.scandb.org) to predict the function of variants within the PLCL1 locus. The strongest signal in this gene is an intronic SNP rs67031482 (p=4.7 × 10−6), which is in LD (R2 = 0.72, D′ = 0.92) with rs1064213 (p = 1.1.×10−4), a missense variant that leads to substitution of a conserved residue valine to isoleucine at position 667 in
