Chunk #76 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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R. Sample 18) Alzheimer’s disease vs control: memory clinic participants: Seven hundred fifty-three AD cases and 736 controls with European ancestry were recruited in Canadian memory clinics. Probable Alzheimer’s disease was diagnosed by clinical criteria, and controls selected who displayed no histories of memory impairment or any impairment on neuropsychological tests [5]. DNAs were subjected to Affymetrix 500k genotyping. From files in http://ctr.gsk.co.uk/Summary/genetic_observational/studylist.asp, p values for each SNP, derived from Fisher’s exact tests, were extracted and data was analyzed as described above.