paperKB
coga / coga-kb
Help
Sign in

Chunk #77 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

Source
Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.
Embedded
yes

Text

S. Sample 19) Individuals with scores on tests of neuroticism 1038 individuals from southwestern England sites with European backgrounds and with high neuroticism (“N”) scores on the revised Eysenck Personality Questionnaire and 1016 individuals with low neuroticism scores (63% female) were studied along with a replication sample of 831 high vs 702 low neuroticism individuals (61% female) [121]. Genotyping of eight pools of DNA from mouth swabs compared: (1) men with high N scores (n = 112), (2) men with low N score (n = 158), (3) men with very high N score (n = 245), (4) men with very low N score (n = 238), (5) women with high N score (n = 320), (6) women with low N score (n = 205), (7) women with very N high score (n = 340) and (8) women with very N low score (n = 436). Very high or low N scores were defined as more than 1.5 s.d. from the mean score adjusted to age and sex (on average 2 s.d.), while high and low N scores were between 1