Genetic analysis can improve the differential diagnosis of neurodegenerative dementias. Standard Sanger sequencing is still a widely used technology, but can be costly and time consuming. NGS technologies offer a faster, less expensive approach, not only for mutation detection but also for transcriptome analysis or epigenetics.198 Several loci have been identified that might be involved in both familial and sporadic forms of neurodegenerative disorders. Understanding the complete genetic mechanisms of AD can provide additional information about the pathological mechanisms of neurodegeneration. GWASs and NGS studies may improve the prevention and treatment of AD.199
