AD is the most common form of senile dementia, but it can sometimes be difficult to distinguish heterogeneous neurodegenerative disorders, such as frontotemporal dementia, dementia with Lewy Bodies, Parkinson’s disease, and Creutzfeldt–Jakob disease.5 AD is a complex disorder, so several genes on different chromosomes could be involved in its onset. Finding the potential genes involved in AD progression is an essential step in molecular diagnosis. Genetic testing should be important to understand the mechanisms and pathways leading to neurodegeneration and disease symptoms. It is believed that disease-modifying therapies are more likely to be effective in the earlier stages of AD, especially before the clinical symptoms appear. Genetic testing in the family members of patients should also be important to predict the risk for disease onset in the future. Using disease markers with genetic testing together may provide more effective disease diagnosis. In addition, the discovery of novel genes may provide more information on AD-related pathways.9,25,196,197
