Thirty high-signal SNPs associated with FEV1/FVC (18 SNPs from eight loci) or FEV1 (12 SNPs from three loci) at or close to genome-wide significance were tested in the SpiroMeta consortium. We evaluated these SNPs in 16,178 SpiroMeta participants of European ancestry with complete quantitative smoking data using the CHARGE analytic method, which included adjustment for smoking status and pack-years, and performed joint meta-analyses of CHARGE GWAS and SpiroMeta replication results (Table 2 and Table 3). P values that exceeded the significance threshold in SpiroMeta (P<8.33×10−4 based on 60 tests) or the genome-wide significance threshold in joint meta-analyses (P<5×10−8) were considered significant evidence for replication.
