Chunk #32 — Results — Application to real data

Source

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations.

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Altogether, our results show that MAF and LD can explain >50% of the loss of accuracy of PGS in individuals of AFR or EAS ancestry, while the RA of PGS in SAS is likely dominated by other factors such as heritability differences or low correlation of causal effects.