We used MAGMA41,42 to conduct a gene-wise TUD analysis and to test for enrichment of pathways curated from multiple sources. After correcting for multiple comparisons, 13 related pathways and biological processes were significantly enriched for genes associated with TUD (p<2.65E-06; Supplementary Table 29). Associations implicated fundamental processes related to nicotine response (e.g., high calcium and sodium permeable nicotinic acetylcholine receptors, p=6.03E-15; behavioral response to nicotine, p=5.81E-13), regulation of postsynaptic nicotinic acetylcholine receptors (p=1.32E-10), and nicotine effect on dopaminergic neurons (p=1.87E-06), among others.
