Next, we used FUMA to examine cell-type specific gene expression associated with TUD, leveraging single-cell RNA-sequencing (sc-RNA seq) datasets. After multiple correction testing across datasets, we identified a significant association between TUD risk and cell-type specific gene expression in GABAergic neurons for individual human sc-RNA seq datasets (Linnarsson, midbrain, gaba: p<5.03E-03; nbGaba: p<4.29E-02; Figure 3d; Supplementary Table 28). These results did not survive conditional analyses within and across datasets.
