Tissue enrichment analyses in MAGMA use gene expression data from GTEx (v8). In addition to non-brain tissues (i.e., cardiovascular, hematopoietic, adrenal pancreas, and other, p<3.37E-05, Supplementary Table 24), we detected significant enrichment mostly in the brain (p=1.53E-15), spanning multiple brain regions, including the hippocampus, the limbic system, frontal cortex (Supplementary Tables 25–26, Figure 3b–c), most of which were also implicated in S-MultiXcan (Supplementary Table 17). Correlating the effects of SNP variation with brain imaging traits via BrainXcan identified similar results, including significant (p<1.92E-04) associations with decreased gray matter volume in the right ventral striatum (Supplementary Table 27).
