Chunk #59 — Online Methods — Genome-wide survival association study datasets — (4) Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
Screening was done with the MMSE and GMS organic level for all persons. Screen-positives (MMSE <26 or Geriatric Mental Schedule (GMS) organic level >0) underwent the CAMDEX. Persons who were suspected of having dementia underwent more extensive neuropsychological testing. When available, imaging data were used. In addition, all participants have been continuously monitored for major events (including dementia) through automated linkage of the study database with digitized medical records from general practitioners, the Regional Institute for Outpatient Mental Health Care and the municipality. In addition physician files from nursing homes and general practitioner records of participants who moved out of the Ommoord district were reviewed twice a year. For suspected dementia events, additional information (including neuroimaging) was obtained from hospital records and research physicians discussed available information with a neurologist experienced in dementia diagnosis and research to verify all diagnoses. Dementia was diagnosed in accordance with internationally accepted criteria for dementia (Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition, DSM-III-R), and AD using the NINCDS-ADRDA criteria for possible, probable and definite AD. The National Institute of Neurological Disorders
