Quillen et al. (2014) performed an AD GWAS in 102 Chinese male AD cases and 212 Chinese male controls from extended pedigrees enriched for AD. Testing for association of AD case-control status with 300,000 SNPs, they identified two GWS loci in the alcohol metabolizing enzyme gene ALDH2, rs3782886 (P=4.74 × 10−8) and rs671 (P=4.73 × 10−8). They also found these SNPs to be strongly associated with the flushing response and maximum drinks consumed in a 24-hour period. The associations with AD are consistent with those from the study by Park et al. (2013) in a Korean sample.
