Park et al. (2013) conducted an AD GWAS in 117 Korean AD cases and 279 Korean controls, testing for association of AD case-control status with over 400,000 SNPs. Despite the small sample, this study identified three GWS associations: two SNPs in the intergenic region flanking the 3’ end of the alcohol metabolizing enzyme gene ADH7 (rs1442492, P = 6.28 × 10−8 and rs10516441, P = 6.46 × 10−8) and a missense SNP in another alcohol metabolizing enzyme gene, ALDH2 (rs671, P=8.42 × 10−8). Similar to Frank et al. (2012), this study suggested that variants in alcohol metabolizing enzyme genes are among the strongest AD risk loci.
