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Chunk #50 — Materials and Methods — Construction of Large-Scale Whole-Brain Functional Connectivity Network

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Development of large-scale functional brain networks in children.
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Wavelets are mathematical functions that transform the input signal into different frequency components [96]. Wavelets methods have previously been applied in the analysis of task-based as well as task-free fMRI signal [35],[97]. In our study, we applied a maximum overlap discrete wavelet transform (MODWT) to each of the 90 regional time series from each subject to obtain the contributing signal in the following three frequency components: scale 1 (0.13–0.25 Hz), scale 2 (0.06–0.12 Hz), and scale 3 (0.01–0.05 Hz). To account for a relatively small number (232) of data points per time series for low frequency correlation analysis, the vector representing the time series beyond its boundaries (<0 and >232) was assumed to be a symmetric reflection of itself. At each of the three scales, wavelet correlations between signals in the 90 anatomical regions were determined by computing the correlation coefficient between the transformed signals at that scale.