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Chunk #51 — Materials and Methods — Construction of Large-Scale Whole-Brain Functional Connectivity Network

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Development of large-scale functional brain networks in children.
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For each subject, a 90-node, scale-specific, undirected graph of the functional connectivity network was constructed by thresholding the wavelet correlation matrix computed at that scale. If the wavelet correlation value between two anatomical regions represented by nodes i and j in the network exceeded a threshold, then an edge was drawn between node i and node j. There is currently no formal consensus regarding threshold selection, so we computed networks for threshold values from 0.01 to 0.99 with an increment of 0.01. Once a whole-brain functional connectivity network was constructed from the correlation matrix, we characterized this network using graph theoretic metrics of global and local brain organization including small-worldness and hierarchy.