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Chunk #63 — Methods — Constructing Repository PGIs — Criterion for Inclusion in Repository

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Resource profile and user guide of the Polygenic Index Repository.
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The previous section described how we generated single-trait and multi-trait input GWASs from which it is straightforward to generate single-trait and multi-trait PGIs for a large number of phenotypes. We now describe how we determined, for each candidate phenotype, whether to include neither the single- nor multi-trait PGI, both PGIs, or one of the two in the initial release of the Repository. The structure of our algorithm is outlined in Figure 2. This section provides the details.