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Chunk #64 — Methods — Constructing Repository PGIs — Criterion for Inclusion in Repository

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Resource profile and user guide of the Polygenic Index Repository.
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For both single- and multi-trait PGIs, we limited the initial set of PGIs released to those with an out-of-sample expected R2 above 1%. While the threshold itself is arbitrary, the decision to have a threshold was driven by two considerations: the value of a PGI for research is increasing in its predictive power, and we worried that a PGI with low predictive power could cause more harm than good if researchers are tempted to conduct underpowered studies.