CNVRs when compared with the random distribution (Supplementary Material, Fig. S1). Table 2.Characteristicsa of the 25 CNVRs related to obesity which were derived from the family-based GWAS discovery sample and sorted by minimal P-valueaGrey rows (1-2,4-17,20-24) indicate regions with evidence for an association with deletions being associated with obesity (as based on the family-based GWAS discovery sample). The 20 directionally consistent results based on both GWAS discovery samples are highlighted in bold (requiring a minimum CNV marker-wise one-sided P-values ≤ 0.025 in the case–control GWAS discovery sample).bChromosomal positions are based on genome build hg 18.cFor details on CNVR-adjusted P-values (based on 10 000 permutations) see section on Permutations and Multiple Testing). Those adjusted P-values that remain significant after Bonferroni correction for the 25 CNVRs tested are underlined.dFor details on the CNV marker correlation, see Quality control section.e‘Both family-based samples’ refers to the family-based discovery GWAS data set and the independent array-based replication data set of families.fFor those two CNVRs the following CNVR-tagging SNPs could be identified: CNVR 11q11 – rs9804659, CNVR 1q31.1 – rs2815752.
