Among the 244 common CNVRs, we detected 25 regions that showed suggestive evidence for an association to (extreme) obesity in the family-based GWAS discovery sample (two-sided asymptotic P-value in the family-based association test for CNVs [CNV-FBAT] ≤ 0.05; Table 2 and Fig. 2). To assess the overall impact of the 25 CNVRs on obesity, we contrasted the effects of their correspondingly involved CNV markers to those of randomly sampled sets of CNV markers chosen from all CNV markers covering the analysed 244 common CNVRs. In a QQ plot (Supplementary Material, Fig. S1), we compared the distribution of the observed association P-values for the 1314 CNV markers covering the 25 detected CNVRs to the distribution of 1000 random sets of P-values for 1314 CNV markers each (expectation under the null hypothesis). We observed stronger obesity association signals for the 25 detected CNVRs when compared with the random distribution (Supplementary Material, Fig. S1). Table 2.Characteristicsa of the 25 CNVRs related to obesity which were derived from the family-based GWAS discovery sample and sorted by minimal P-valueaGrey rows (1-2,4-17,20-24) indicate regions with evidence
