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Chunk #14 — Results — Genetic relationship of OCD with other phenotypes

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Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.
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Using phenome-wide association analysis, we examined whether the 30 independent OCD-associated loci identified by our GWAS meta-analysis have previously been associated with other phenotypes (see Supplementary Tables 17a–d for lookups in four, partially overlapping GWAS databanks and Table 1 for highlighted associations). We found that 22 of the 30 loci were associated with other phenotypes, including schizophrenia (seven loci), depression and major depressive disorder (two loci), bipolar disorder (one locus), neuroticism (seven loci), educational attainment (seven loci) and body fat mass or body mass index (eight loci).