We further used bivariate linkage disequilibrium score regression (LDSC)31 to investigate the extent of genetic correlations between OCD and 112 previously published GWASs encompassing psychiatric, substance use and neurological phenotypes, among others (Fig. 3). We found that 65 phenotypes were significantly correlated with OCD after correcting for multiple testing using the Benjamini–Hochberg32 procedure to control the false discovery rate (FDR) at a threshold of 0.05. OCD was significantly positively correlated with all tested psychiatric phenotypes; the highest correlations were with anxiety (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.70$$\end{document}rG=0.70), depression (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.60$$\end{document}rG=0.60), anorexia nervosa (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.52$$\end{document}rG=0.52), Tourette syndrome (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.47$$\end{document}rG=0.47) and post-traumatic stress disorder (PTSD; \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.48$$\end{document}rG=0.48). Significant positive genetic correlations were also obtained for neuroticism (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.53$$\end{document}rG=0.53), in particular for the worry subcluster (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.64$$\end{document}rG=0.64), and all individual items
