Chunk #16 — Results — Genetic relationship of OCD with other phenotypes

Source

Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.

Embedded

yes

Text

\begin{document}$${r}_{\rm{G}}=0.48$$\end{document}rG=0.48). Significant positive genetic correlations were also obtained for neuroticism (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.53$$\end{document}rG=0.53), in particular for the worry subcluster (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.64$$\end{document}rG=0.64), and all individual items in the worry subcluster, with slightly lower estimates for the depressive subcluster (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.35$$\end{document}rG=0.35). Suicide attempt (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.40$$\end{document}rG=0.40), history of childhood maltreatment (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.37$$\end{document}rG=0.37) and tiredness (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.36$$\end{document}rG=0.36) were also notable for strong positive associations with OCD. Of the assessed neurological disorders, OCD was only significantly correlated with migraine (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=0.15$$\end{document}rG=0.15). Some autoimmune disorders, such as Crohn’s disease (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=-0.13$$\end{document}rG=−0.13), ulcerative colitis (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=-0.14$$\end{document}rG=−0.14) and inflammatory bowel disease (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\rm{G}}=-0.14$$\end{document}rG=−0.14), showed negative correlations with OCD (see Fig. 3 and Supplementary Table 18 for all genetic correlation estimates, 95% confidence intervals and P values, Supplementary Note 6